Nutritional Deficiencies

  1. Iron Deficiency Anemia
  2. Vitamin B12 Deficiency (Pernicious Anemia)
  3. Folate Deficiency Anemia

Hemoglobinopathies

  1. Sickle Cell Disease (SCD)
  2. Thalassemias
  3. Hemoglobin C Disease
  4. Hemoglobin SC Disease
  5. Hemoglobin E Disease
    • .

RBC Membrane Disorders

  1. Hereditary Spherocytosis
  2. Hereditary Elliptocytosis (Ovalocytosis)
    • Southeast Asian Ovalocytosis

    RBC Enzyme Deficiencies

    1. Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency
    2. Pyruvate Kinase Deficiency
    3. Other Enzyme Deficiencies

      Acquired Hemolytic Anemias

      1. Autoimmune Hemolytic Anemia (AIHA)
      2. Microangiopathic Hemolytic Anemia (MAHA)
      3. Paroxysmal Nocturnal Hemoglobinuria (PNH)

      Aplastic and Hypoproliferative Anemias

      1. Aplastic Anemia
        • Pure Red Cell Aplasia
        • Anemia of Chronic Disease (ACD)

        Polycythemias (High RBC Count)

        1. Polycythemia Vera (PV)
        2. Secondary Polycythemia
        3. Relative Polycythemia

        Other/Overlap Categories

        1. Myelodysplastic Syndromes (MDS)
        2. Anemia of Chronic Renal Failure
        3. Anemia of Endocrine Disorders


        When to Seek Medical Attention

        • Persistent fatigue, dizziness, or shortness of breath.
        • Rapid heart rate or palpitations.
        • Unusual paleness, jaundice, or dark urine.
        • Headaches, blurred vision, or itching (especially after a hot bath in polycythemia).

        Diagnosis & Management

        Most RBC disorders can be diagnosed with a Complete Blood Count (CBC), peripheral blood smear, and follow-up tests (e.g., hemoglobin electrophoresis, enzyme assays, bone marrow biopsy). Treatments vary widely—ranging from dietary supplements and medication to blood transfusions, phlebotomy (for polycythemia), or advanced therapies like stem cell transplants.


        Disclaimer: This list is provided for general educational purposes and does not replace professional medical advice. If you suspect you may have an RBC disorder or any other health condition, please consult a qualified healthcare provider for personalized diagnosis and treatment.